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Item ЗДОРОВЕ ДОВГОЛІТТЯ ЛЮДИНИ ТА РУХОВА АКТИВНІСТЬ: ОЧЕВИДНІСТЬ І НЕВИРІШЕНІ ПИТАННЯ(2025) Гуніна-Орлова Л. М.; Орлов О. І.; Данильченко С. І.У роботі доведено, що якість життя відображає добробут людини, охоплюючи фізичне й психічне здоров’я, освіту, стосунки, безпеку, соціальний статус і свободу. На якість життя впливають сон, рухова активність, харчування, звички. Встановлено, що ослаблені люди похилого віку, отримують користь від рухової активності, але для об’єктивізації впливу фізичних втручань необхідно використовувати не лише різноманітні якісні методи контролю (анкетування, опитування), але, й в першу чергу, об’єктивні методологічні підходи із застосуванням методів доказової медицини. Ключові слова: рухова активність, довголіття, фізичне навантаження, методи контролю, фізичні вправи.Item NEW WAYS TO ADDRESS THE PROBLEM OF CHRONIC NON-COMMUNICABLE DISEASES(2025) Nevoit G.; Poderiene K.; Danylchenko S.; Potyazhenko M.; Mintser O.; Jarusevicius G.; Vainoras А.The review is devoted to the search for new directions for solving the problem of chronic non-communi- cable diseases in the future. The term «Non-communicable diseases» (NCDs) refers to chronic diseases of internal human organs that are not transmitted from one person to another. This term was first used by the medical academic community and the World Health Organization at the end of the 20th century after the understanding of the common pathogenesis of all non- communicable diseases deepened. All non-communicable diseases have a long duration of course/catamnesis and are the result of a combination of genetic, physiological, environmental, and behavioral factors. Results. As a result of the theoretical study, the following promising scientific directions for solving the problem of NCDs in the future were identified: • Mitochondrial dysfunction as a new trend in the pathogenesis of NCDs and a new therapeutic target; • Continuum of NCDs is a new model for their catamnesis; • The Theory of Complex Systems of the human body is a new approach to the systemic study of NCDs; • The promising role of Magnetobiology in the search for new mechanisms of the pathogenesis of NCDs; • Frequency-wave model of the human body structure is a promising direction in the search for new methods of diagnosis and treatment of NCDs; • Kinesiotherapy and regular exercise are scientifically based ways to overcome mitochondrial dysfunction and NCDs. The purpose of this perspective review was to identify new promising directions in solving the problem of chron- ic non-communicable diseases from the standpoint of modern biophysical knowledge. Materials and methods: general scientific and theoretical methods were used in the theoretical study. The results of the system analysis of existing new scientific knowledge, which can form the basis for new approaches to solving the problem of chronic non-communicable diseases, are presented in the review. Conclusions. The most promising areas were identified as areas related to deepening knowledge of the pathogenesis of chronic non-communicable diseases as the basis of pathology. These are studies devoted to the role of mitochondria, the creation of new ideas about the continuum of chronic non-communicable diseases, the search for new mechanisms of pathogenesis of chronic non-communicable diseases based on new knowledge of magnetobiology, and deepening knowl- edge about the role of the myofascial system in the energy supply of the human body. Of fundamental importance is the development of ideas of the theory of the human body as a complex system by the professor. A. Vainoras. A promising direction is the study of the possibilities of instrumental diagnostic complexes based on the Vega test and bioresonance therapy in the complex management and treatment of patients with chronic non-communicable diseases.Item THEORETICAL BASES OF RECOVERY OF ATHLETES AFTER INJURIES AND OPERATIONS(2025) Kovalyova K. I.; Golovchenko I. V.; Danylchenko S. IThe purpose of this study was to analyze modern methods and strategies for the restoration of athletes after injuries and operations, as well as to evaluate their effectiveness based on practical research. Object and research methods. Analysis of scientific literature and modern research in the field of rehabilitation of athletes. Review of medical, physical and innovative methods of recovery of athletes. Results. According to many researchers, sports competitions are one of the most dangerous in terms of injury to the musculoskeletal system. Sport is leading the number of injuries, mainly due to rapid changes in the movement during the game and the need to make quick and effective decisions in a limited time. In addition to physical training, athletes are subjected to considerable neurological and psychological stress during competitions, accompanied by intense emotional experiences. This is due to, in particular, physical contact, frequent jumps, sprints and sharp turns, which often contribute to the occurrence of sports injuries. Experienced athletes who compete at a high level of more than 10 years are most injured. The main purpose of the rehabilitation process is to reduce the degree of injury, reduce or restore disorders and func- tional losses, as well as prevent, correct or completely eliminate disability. The rehabilitation process is overseen by a multidisciplinary team, which includes a doctor, sports doctors, physical therapists, orthopedists, physiotherapists, rehabilitologists, physical educators, sports coaches, psychologists and nutri- tionists. The team works with the athlete and the trainer to determine the goals of rehabilitation, evaluate progress and set the time of return to training and competitions. Proper goals are key to sports rehabilitation, as it can significantly speed up the recovery process after injury. The goals should be clearly defined, measured and formulated in specific behavioral terms. Studies show that goals should be ambitious but achievable. It is important to focus on short -term goals as steps to achieve long -term results. Psychological recovery involves working on adaptation to changes in physical condition and new training condi- tions. Athletes need to learn to adapt to new or altered physical abilities and find new strategies to achieve high results. This may include adaptation of exercise technique, changing training strategies, or even developing new sports skills. The psychological component of rehabilitation includes aspects of restoring self -confidence. The gradual achievement of realistic goals, positive reinforcements and achievement of intermediate successes help to restore confidence. The reha- bilitation program should include tasks that gradually increase the complexity, allowing the athlete to experience gradual progress. Improving the quality of the rehabilitation process and, as a consequence, the success of the return of athletes to active sports activities is influenced by reasonable recommendations for the use of various methods of recovery in sports practice used to develop individualized rehabilitation programs. Conclusions. Successful restoration of athletes after injuries involves a comprehensive approach that covers both physical and psychological aspects. Interaction between physical and psychological components of rehabilitation helps athletes not only to restore their physical form, but also to return to competitions with new confidence and motivation.Item ПРОФЕСОР ОЗАР МІНЦЕР: ЗУСТРІЧАЮЧИ 85-РІЧНИЙ ЮВІЛЕЙ ІНОВАЦІЯМИ В МЕДИЧНІЙ ПАРАДИГМІ(2025) Невойт Г.; Подерієне К.; Данильченко І.; Кітура О.; Потяженко М.; Ярущавічус Г.; Вайнорас А.; Суханова О.У червні 2025 року виповнюється 85-років із дня народження видатного українського вченого проф. Озара Петровича Мінцера. У цій статті представлено короткий огляд напрямків результатів наукових дослі- джень, над якими останні роки працює цей видатний науковець України. Мета – популяризація сучасних медич- них знань серед академічної спільноти України заради прогресивних змін у науковій парадигмі. Матеріали і методи. Загально наукові методи та системний аналіз літератури було використано. Висновки. 1) Професором О. Мінцером було зроблено значний фундаментальний внесок у розвиток меди- цини завдяки сприянню інтеграції у неї медичної інформатики, у тому числі штучного інтелекту та цифрових технологій навчання та статистичних систем баз даних у медицині. 2) Дослідження інформаційних аспектів здоров’я і концептуалізація Магнітоелектрохімічної теорії є нова- торськими науковими напрямками у медицині, які відкривають новітні горизонти для розуміння квантових ме- ханізмів передачі енергії і інформації у тілі людини, вивчення квантового патогенезу захворювань внутрішніх органів і створення новітніх напрямків квантових галузей у медичній науці. 3) Квантова роль м’язів, концепція біофотонового сигналінгу, квантова роль мітохондрій, роль біофотонів у міжклітинній і організменний комунікації у тілі людини є важливим фундаментальним внеском у медичну науку і є перспективними науковими трендами для створення новітніх наукових напрямків досліджень. 4) Навчально-науковий проєкт «Біоелектронна медицина або Подивись на медицину інакше» за участю і ке- рівництвом професора О. Мінцера надає академічній спільності можливість використання новітніх новаторських ідей, концептів, знань у подальшій трансформації і розвитку наукової медичної парадигми.Item LABORATORY MARKERS FOR OVERLOAD OF THE CERVICAL SPINE(2025) Leontieva F. S.; Fedotova I. F.; Morozenko D. V.; Danylchenko S. I.Recently, the number of applications from patients who have significant physical exertion in conditions of prolonged exposure to stress factors has increased significantly. Spinal overload is a rather serious and important factor that contributes to the development of degenerative changes, as well as metabolic disorders of various kinds that occur in conditions of chronic stress. In clinical and fundamental medicine, most of the clinical and pathophysiological changes in the human body that occur under the influence of chronic stress and contribute to the development of metabolic disorders during spinal overload remain incompletely understood. This problem is especially important and relevant today for the military, who, during the difficult fight against armed aggression in conditions of chronic stress, have significant physical exertion, which is reflected in the condition of the spine. The aim of the study is to identify the most modern laboratory markers of metabolic disorders during spinal overload. Materials and methods. The scientific data of the PubMed platform for 2021– 2025 were analysed. Results The dynamics of clinical and functional disorders in the body of patients with cervical spine overload on the background of chronic stress includes a complex of structural, functional changes and neurological disorders, which in the case of a long course lead to the development of degenerative diseases of the spine. The conceptual scheme of the formation of metabolic disorders in patients with cervical spine overload on the background of chronic stress consists in the consistent and gradual development of clinical and metabolic disorders, which are reflected in structural and functional changes and clinical and laboratory indicators of blood and urine. The direction of research on the development of criteria for assessing and preventing the impact of chronic stress on the human body with spinal overload can be considered promising. Among the most informative markers that can be used to examine patients are the following: C-reactive protein (may increase in the blood due to inflammation of muscle tissue and/or ligaments in the neck area), integral leukogram indicators (changes in the ratio of leukocytes – leukocytosis, lymphocytopenia or neutrophilia may be detected in patients as reactions to stress); interleukin-1 (often increases in the blood during chronic stress and is associated with inflammation), as well as interleukin- 10 (has an anti-inflammatory effect and may decrease during chronic stress). Conclusions. The most effective laboratory markers for assessing the condition of patients with cervical spine overload on the background of chronic stress can be considered inflammatory markers, marker enzymes for assessing muscle tissue, indicators of insulin resistance, hormonal metabolism and interleukins.Item PERSONALIZED REHABILITATION STRATEGIES FOLLOWING LOWER LIMB AMPUTATION: CLINICAL AND FUNCTIONAL OUTCOMES(2025) Danylenko A. S.; Danylchenko S. I.; Fursenko A. О.; Morozenko D. V.; Chorna I. O.Objective. The objective of this study was to evaluate the effectiveness of a physical rehabilitation protocol for patients following lower limb amputation, taking into account prosthetic fitting specifics and gait skill development. Materials and Methods. The study included 20 patients with transtibial amputations. The rehabilitation program integrated therapeutic exercise, physiotherapy, massage, robotic-assisted technologies, and psychological support. Effectiveness was assessed using indicators of muscle strength, balance, coordination, functional mobility, and quality of life. Results. Implementation of the program led to significant improvements in rehabilitation outcomes. Patients demonstrated measurable gains in lower limb muscle strength, enhanced postural control, improved coordination, and better walking parameters. Average gait speed increased by more than 20%, and step length and cadence became more symmetrical compared to baseline. In the 6-Minute Walk Test, patients extended their average walking distance from 260 m at baseline to 320 m after completing the program, indicating greater endurance. Balance performance also improved, with mean Berg Balance Scale scores rising from 42 to 48 points, reflecting more stable mobility. Functional mobility scores increased across all amputation levels, with transtibial amputees showing the most pronounced progress. Importantly, the structured protocol reduced rehabilitation duration by approximately 3 weeks on average and facilitated earlier adaptation to the prosthesis. Psychological support played a crucial role in helping patients overcome fear of falling, enhancing motivation, and promoting consistent use of the prosthesis in daily life. Overall, the combined multidisciplinary approach ensured higher mobility levels, faster reintegration into daily activities, and substantial improvements in self-reported quality of life across both physical and psychosocial domains. Conclusions. The proposed rehabilitation program proved effective for optimizing recovery after lower limb amputation. Its application in clinical practice can improve functional outcomes and quality of life and may be recommended for wider use in rehabilitation services.Item PHARMACOGENETIC ASPECTS OF THERAPY FOR AUTOIMMUNE HEPATITIS AGAINST THE BACKGROUND OF DEGENERATIVE-DYSTROPHIC JOINT LESIONS.(2025) Borysenko T. V.; Babalian V. O.; Dorofieieva V. R.; Danylchenko S. I.; Fedota О. М.Introduction and aim. The pathogenesis of autoimmune diseases, including musculoskeletal, gastrointestinal, and endocrine manifestations, involves the interaction of genotype and environmental factors. Pathologies demonstrate comorbidity and clinical heterogeneity even within a single family. Genetic polymorphisms of one-carbon metabolism are key regulators of cel- lular processes that become therapeutic targets. Description of the case. The study describes personalized therapy for a patient with an autoimmune comorbid disease, with an emphasis on genetic and metabolic characteristics. The treatment regimen is adapted to the features of the one-carbon metabolism profile of a patient with chronic autoimmune hepatitis and degenerative-dystrophic joint disease. Family history includes autoimmune thyroiditis, vitiligo, Parkinson’s disease, cardiovascular diseases. The patient’s genotype for single nucleo- tide polymorphisms rs1801133, rs1801131, rs1801394, rs1805087, and rs3733890 of the one-carbon metabolism genes is asso- ciated with elevated plasma homocysteine levels. After treatment, changes in biochemical parameters were observed: alanine aminotransferase (72→53 U/L), aspartate aminotransferase (53→44 U/L), gamma-glutamyltransferase (129→89 U/L), alkaline phosphatase (313→125 U/L) and homocysteine (15.1→17.0 μmol/L). Conclusion. Positive dynamics after personalized therapy demonstrates the importance of an interdisciplinary approach to etio- pathogenetic treatment, emphasizing the need to support hepatobiliary function along with muscular and skeletal therapy.Item MAGNETOELECTROCHEMICAL THEORY OF METABOLISM AND LIFE IS A NEW TREND IN COMPLEXITY IN HEALTH SCIENCES(2025) Nevoit G.; Poderiene K.; Danylchenko S.; Kitura O.; Liulka N.; Golovchenko I.; Potyazhenko M.; Mintser O.; Jarusevicius G.; Vainoras A.In 2018, research was initiated to investigate the role of electromagnetic processes in human metabolism. This theoretical research is part of the research work of the Department of Internal Medicine and Emergency Medicine of Poltava State Medical University (23, Shevchenko St., 36011, Poltava, Ukraine) on “Development of algorithms and technologies for implementing a Healthy Lifestyle in patients with Non-Communicable Diseases (NCDs) based on the study of functional status” (state registration number 0121U108237: UDC 613 616-056-06: 616.1/9-03). The results of this work were embodied in the conceptualization of the Magnetoelectrochemical Theory of Metabolism and Life. The purpose of this article is to present to the academic community brief information about the results of the research work carried out in this direction for the further development of these scientific ideas and their integration into the scientific paradigm. Conclusions: 1) Magnetoelectrochemical Theory of Metabolism and Life is a new trend in Complexity in Health Sciences. 2) The biophysical direction of development of modern medicine opens up new ways to solve the problems of diseases of internal organs. 3) Knowledge of the fundamental aspects of electromagnetic communication of cells of the human body is a new basis for deepening the fundamental knowledge of the pathogenesis of diseases of internal organs, and this is a new promising direction for further research. 4) Bioelectronic Medicine, as a new component of medical science, is based on and directs therapeutic influence on the quantum levels of the structure and functioning of the human body. 5) The initiative educational and scientific project “Bioelectronic Medicine or Look at Medicine Differently” is a practical attempt in the conditions of the scientific present to find a way to change the scientific paradigm and popularize the latest knowledge among the academic community of the biomedical direction. 6) The practical application of this knowledge opens up new avenues for the further development of Magnetobiology, Internal Medicine, Microbiology, and Traditional Medicine. It can ensure progres in the treatment of diseases of internal organs, whether infectious or non-infectious in origin.Item HOW ARTICLES ARE PREPARED FOR PUBLICATION IN THE SCIENTIFIC JOURNALS OF THE KHARKIV NATIONAL(2025) Nakonechna O. A.; Shevchenko A. S.; Danylchenko S. I.; Korneiko I. V.Kharkiv National Medical University (KhNMU) is the founder and publisher of periodical (quarterly) peer-reviewed scientific journals of open access "Medicine Today and Tomorrow" (ISSN print 2414-4495, ISSN online 2710-1444), "Experimental and Clinical Medicine" (ISSN print 2414-4517, ISSN online 2710-1487) and "Inter Collegas" (ISSN online 2409- 9988). We have analyzed the work with manuscripts of articles of these journals and present readers with a detailed description of the procedures that should help the authors of articles to effectively cooperate with the editors of these scientific journals in preparing their articles for publication. The article will also be useful to members of editorial boards and editorial councils of journals. This publication will help article reviewers determine their readiness for the procedure. We described both the existing rules and procedures for working with manu- scripts, as well as the changes that will come into force from the beginning of July 2025. The article describes the structure of the manuscript, issues of ethics of the researcher and author, copyright, plagiarism checking, reviewing and editing of manuscripts, the policy of the jour- nal in cases of violation of ethics, the mission of the journals. The editorial board uses a double blinded peer review procedure with the participation of at least two reviewers for each article. Reviewers are invited by editors. The reviewers have the appropriate specialization and ex- perience in the subject matter of the articles they propose. The editorial board is loyal to the lack of experience of young authors, but is intolerant of falsification of research results and plagiarism, creating conflict situations while working on manuscripts. The publication of ar- ticles and their further use is under the terms of the Creative Commons license (BY-NC-SA). The editorial board relies on the principles of evidence-based medicine and publishes articles that contain contradictory issues from the point of view of evidence with a note about their disagreement with the position of the authors.Item FEATURES OF DIAGNOSTICS OF FATAL KIDNEY INJURY IN MEDICAL PRACTICE(2025) Babkina O.; Danylchenko S.; Korobko I.; Yanchevskyi O.; Kravchenko A.Aim: To examine how temperature changes over time in injured and uninjured kidney tissues, based on the time elapsed since trauma and death. Additionally, develop a regression model to estimate the time of death using temperature measurements from the abdominal organs. Material and Methods: The study included data from 256 individuals (both males and females aged 20–60 years) who died from mechanical trauma. Tissue temperatures were measured using infrared thermometry at various times within 24 hours after death. The analysis covered temperature measurements of the liver, spleen, pancreas, kidneys, skin, and the thickness of subcutaneous fat tissue. Results: Determining the exact time of death remains a complex aspect of forensic practice, especially in cases involving traumatic injuries. Often, the moment of injury does not match the time of death: the person may die immediately at the scene or after some delay—during transport or at a medical facility. Therefore, distinguishing between the “time of injury” and the “time of death” is crucial for accurate forensic evaluation. A statistically significant decrease in temperature was observed in both injured and uninjured kidney tissues. The temperature in the injured areas stayed consistently higher by 2–3 °C (±0.28) compared to uninjured regions. The temperature difference between the right and left kidneys was 1.5–2 °C (±0.14), likely due to anatomical factors that offer greater protection to the right kidney. The sex of the deceased did not affect temperature indicators. A regression model was created to estimate the time of death with high accuracy (R² = 0.86), including temperatures of several parenchymal organs, skin temperature, subcutaneous fat thickness, and ambient temperature. All predictors in the model were statistically significant (p < 0.05). Conclusions: The developed multivariate regression model, which considers temperature parameters of injured and uninjured parenchymal organs, serves as a promising tool for forensic estimation of the time of death. Our study's findings emphasize the potential of infrared thermometry in forensic practice as a quantitative method for determining the post-injury interval and the time of death.